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Bare hos et mindretall er det funnet kjente sykdommer som kan medføre langvarig smerte, for eksempel artrose, revmatiske sykdommer eller nervelidelser.1897: Den tyske kjemikeren Felix Hoffmann i firmaet Bayer fremstiller det smertestillende legemiddelet acetylsalisylsyre. Utgangsstoffet salisylsyre hadde imidlertid blitt brukt i årtusener i folke

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